Blackler R, et al. Antibody Engineering & Therapeutics US, December 2023
This poster describes the identification of antibodies against an established GPCR target, chemokine receptor 8 (CCR8). Hundreds of diverse antibodies were discovered using protein- and DNA-based immunizations coupled with microfluidic single-cell screening. High-throughput function-based screening was used to down-select antibodies based on ADCC reporter activity. Antibodies were optimized for developability using structure-guided protein engineering technologies paired with high-throughput antibody assessment. Selected antibodies show strong ADCC reporter activity similar to a clinical benchmark and favorable developability properties.
